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Garbage In, Garbage Out - FFPE Samples for NGS Success

Posted by Jenny Hsu on Mar 9, 2016 11:00:00 AM

We are all familiar with the end-to-end NGS workflow, starting with sample preparation, followed by sequencing, bioinformatics and interpretation. While at Bina we are largely focused on informatics, the analysis and insight that we gather from sequencing data are only as good as the samples going in. Formalin-fixed, paraffin-embedded (FFPE) tissue samples are pertinent in the clinical and translational oncology setting. However, nucleic acids extracted from FFPE samples are often fragmented, in low yield, and chemically modified, making them difficult to use in genetic and next- generation sequencing studies.

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Topics: Events & Conferences, Molecular Med, FFPE, NGS, TRICON

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